Local activation of the alternative complement pathway (AP)  in the mesangium influences the extent of glomerular injury...

Tegoprubart is a next generation monoclonal antibody directed against CD40 ligand (CD40L; CD154)...

IONIS-FB-LRx is a ligand-conjugated (LICA) investigational antisense medicine designed to reduce the production of complement factor B (FB)...

Increased production of ET 1 has been associated with  progression of IgA nephropathy...

Local complement activation in the mesangium appears to influence the extent of glomerular injury in IgAN

Some patients with IgAN have lectin pathway activation (as determined by glomerular deposition of mannose-binding lectin [MBL]...

BION-1301 is a novel humanized anti-APRIL monoclonal antibody. APRIL stands for A PRoliferation-Inducing Ligand....

Atrasentan is an Endothelin A (ETA) receptor antagonist which has been studied extensively in diabetic kidney disease...